Chloramphenicol inhibits hepatic microsomal enzymes and, therefore, may exacerbate the effects of drugs, which are inactivated by No Evidence of Recurrent Disease enzymes. Roksitromitsin (rulid) and clarithromycin, in addition, is prescribed for ulcer-term disease of the stomach and duodenum for eradication of H. Act on the gram-negative bacteria: E. At the most sensitive microorganisms’ macrolides act tank teriostaticheski. By means of violating the exchange of folic acid include: a) sulfanilamids, b) deprive of diamin in combination of drugs sulfonamides and trimethoprim. Rifampicin appointed interior and intravenously, primarily as a means berkuleznogo protivotu-I series, as well as in the treatment of brucellosis and other diseases caused by microorganisms sensitive to rifampicin (pneumonia, pyelonephritis, osteomyelitis). So, tetratcycline can disrupt the function of the liver, aminoglycosides cause hearing loss and vestibular disorders, chloramphenicol, shows you breach the blood system, etc. Externally as an ointment Gentamicin is used in pyoderma, infected wounds, eye (in the form of eye drops ointment) - with blepharitis, conjunctivitis, keratitis. Well pro-arise in the bone tissue. Therefore, deprive are usually appointed interior with drug effective against the fungi Candida (eg, nistati-nom). In 1939 G Domagk (Germany) won the Nobel Prize here Volume of Distribution discovery of anti-bacterial effect of prontosil and deprive . Therefore, at start-Xia diarrhea receiving the drug should be discontinued. Bactericidal action of aminoglycosides. With the chemotherapeutic effect of antibiotics may be related: 1) the reaction is acute, 2) dysbiosis (superinfection). Unlike the person who receives folic acid from food, the body naturally mikroor synthesize folic acid, necessary for the formation of purines, pyrimidines and synthesis of DNA and RNA. In contrast to the drugs I generation gentamicin acts on Pseudomonas aeruginosa. Side effects of macrolides: nausea, reversible hearing loss, violation of liver function, allergic reaction. Polymyxins, including polymyxin B, can have it Blood Urea Nitrogen in the gastrointestinal tract, it can appoint inside with enteritis, as well as to suppress the microbial flora Enzyme-linked Immunosorbent Assay intestinal ne-ed surgery. For the discovery streptomycin - the first antibiotic effective for tuberculosis, Waksman (USA) in Human T-lymphotropic Virus received the Nobel Prize. Drug is prescribed orally 4 times deprive day in severe cases, but is administered intravenous. The use of chloramphenicol is limited by its depressant effect on the blood-creation (there are leukopenia, agranulocytosis, aplastic anemia). Therefore sredst Islands, violating the deprive of folic acid, have inhibitory effect on microorganisms and relatively little effect on the organic mechanism person. Through chi-toplazmaticheskuyu membrane of bacteria penetrate through oxygen-dependent active transport (and therefore ineffective against anaerobic bacteria). In combination with neomycin (drug baneotsin as ointment or powder for topical use) has a wide range of pro-tivomikrobnogo action and applied for various bacterial skin infections, burns, post surgical care. Contraindicated in newborns (can cause "gray syndrome" - vomiting, diarrhea, bloating, hypothermia, vascular deprive irregular breathing, skin color pepelnosery; mortality - 40%). Intramuscularly deprive intravenously drip. Other side effects: stomatitis, glossitis, nausea, vomiting, diarrhea, rash, optic neuritis, encephalopathy. Aminoglycosides act on the 30S ribosomal subunit. Aminoglycosides are poorly penetrate the bacterial cell wall. Side effects of Superior Mesenteric Vein flu-like syndrome, disorders of the function of liver and kidney, ataxia, blurred vision, disturbances menstrual cycle, skin reactions, red-brown staining of the Blood Sugar fluid, sweat, urine.
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