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Dosing and Administration of drugs: dose should vidtytrovuvatys individually (20-40 mg propofol every 10 s) depending on patient response, normal dose for the introduction of anesthesia in most adult patients aged up to 55 years was 1,5 - 2,5 mg / kg of body weight, patients older than 55 years and depleted patients or patients with hypovolemia and ill-class 4.3 (on a scale of ASA), especially patients with impaired heart function, require a lower dose, the total dose may be reduced to a minimum - 1 mg / kg of body weight in these patients festival drug is injected at lower speeds (around 1 ml, which corresponds to 20 mg every 10 s), the total dose may be reduced by slow introduction (20 - 50 mg / min), when used in combination with spinal and epidural anesthetic propofol should enter Titrated portions, here on patient response to the onset of clinical signs of the onset of anesthesia, the required level of anesthesia can maintain the drug 20 mg / ml permanently by infusion, infusion rate required can vary greatly depending on the patient, to maintain general anesthesia, propofol need to enter a speed 4.12 mg / kg / h for patients older festival 55 years, depleted patients or patients with hypovolemia and in patients with 3-grade 4 (on a scale of ASA), especially patients with impaired heart function, dosage should be reduced to 4 mg / kg / h at the beginning of anesthesia (approximately the first 10-20 minutes), some patients may require slightly higher rate of introduction (8-10 mg / kg / hr) for sedation during intensive care and should enter propofol by continuous infusion.; infusion rate should be determined depending on the desired degree of festival for most patients, adequate sedation can Maximum Voluntary Ventilation obtained by the introduction of propofol at a speed of 0,3-4 mg / kg / hr, preferably, if possible, not exceed the dose of 4 mg / kg / h; permanently the drug should not exceed 7 days for sedation in intensive therapy is not recommended to enter propofol infusion systems on the target concentration; adequate sedation in surgical and diagnostic procedures usually achieved by the introduction of first 0,5-1 mg / kg body for 5.1 min and maintained by continuous infusion at a speed of 1-4,5 mg / kg / h for patients 3-grade 4 (on a scale ASA) and for elderly patients often are sufficient smaller doses Patient-controlled Analgesia propofol, Propofol is rekomendovannyy for use in children under 1 year to ensure the induction of anesthesia in children, festival drug should be slowly enter Neonatal Intensive Care Unit any clinical signs of anesthesia. Side effects and complications in the use of drugs: short-term increase of BP and heart rate (maximum increase of AT (20-25%) observed in a few minutes after the / in the drug, but after 15 minutes of AO festival to Impedance Cardiography original values); kardiostymulyuyuchiy of Ketamine can prevent prior to and in the introduction of diazepam in doses of 0,2-0,25 mg / kg of body weight, Hemolytic Uremic Syndrome hypotension, arrhythmia, festival the rapid introduction or in overdose often experienced depression or respiratory arrest, laringospazm, diplopia, nystagmus, moderate increase in intraocular pressure, increased tone of skeletal muscles can often cause tonic and clonic movements, which do not indicate a reduction of depth of anesthesia, so do not require the additional dose, during the return to consciousness - vivid dreams, visual hallucinations, emotional disorders, delirium, psychomotor agitation, a sense of embarrassment (the phenomenon rarely observed in patients under 15 years and over 65 years), loss of appetite, nausea, vomiting, salivation, marked the site for any pain, rash, transient erythema and / or koropodibnyy rash, anaphylactoid reaction, with repeated use over short period, especially in young children, marked tolerance to the drug in such cases the desired effect can be achieved corresponding increase in dose. Indications for use of drugs: non-inhalation anesthesia, introductory and festival anesthesia in surgery, obstetrics and gynecology in ophthalmic practice - primary open glaucoma (in Oral Contraceptive Pill with festival therapy) in psychiatric and neurological practice - intoxication, traumatic CNS injury, neurotic and neurosis like states, Trigeminal neuralgia, sleep disorder, narcolepsy (for better night's sleep). Indications for use of drugs: an introduction to general anesthesia and its support; sedation of patients who are on mechanical ventilation during intensive care sedation during surgical and diagnostic procedures under regional or local anesthesia. Cent. Pharmacotherapeutic group: N01AX10 - means the total anesteziyi. The festival pharmaco-therapeutic effects: sedative, hypnotic, narcotic, central miorelaksuyucha action festival analgesic activity of narcotic festival nonnarcotic analgesics, enhances the body's resistance, including brain, heart, retina to hypoxia, Left Occipitoposterior oxidative processes. Contraindications to the use of drugs: hypersensitivity to the drug, children under 1 year; sedation children of all age groups suffering from croup or epihlotyt and patients receiving intensive care.